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The team of Academician Ge Junbo at Zhongshan Hospital, Fudan University completed China's first transcatheter aortic valve replacement (TAVR) in 2010, pioneering Chinese valve intervention.

Zhongshan Hospital completed the world's first percutaneous aortic valve replacement using a polymer valve, with roughly twice the material lifespan of a traditional bioprosthetic valve.

Fuwai Hospital completed China's first implant of the original Venus-A transcatheter valve, opening clinical research on self-developed interventional valves.

Zhongshan Hospital completed the world's first percutaneous pulmonary valve replacement using the original Venus-P valve.

West China Hospital cardiology completed the world's first human implant of the original pre-loaded dry valve Venibri.

Professor Ma Changsheng of Beijing Anzhen Hospital completed China's first atrial fibrillation catheter ablation in 1998, systematically establishing the technique in China.

Fuwai Hospital completed China's first cryoballoon catheter ablation for atrial fibrillation in 2012.

West China Hospital cardiac surgery completed China's first interventional-robot + TAVR (S3) clinical trial implant.

West China Hospital completed one of the first nationwide clinical implants of a new-generation dual-chamber leadless pacemaker, entering the physiological pacing era.

West China Hospital implanted the purely domestic third-generation magnetically-levitated ventricular assist device, changing the situation where end-stage heart failure relied only on heart transplant.

Fuwai Hospital and Tongxin Medical completed the first CH-VAD implant, making history in Chinese artificial heart clinical application.

Shanghai Changhai Hospital completed the world's first clinical implant of a branched thoracic aortic stent-graft for endovascular treatment of aortic-arch dissection.

The team of Dou Kefei at Fuwai Hospital completed the world's first fully robot-assisted coronary angiography.

The team of Zhang Bili at Shanghai Changhai Hospital completed China's first domestic-robot-assisted fully remote coronary intervention.

The team of Zhao Weili at Ruijin Hospital completed China's first commercial CAR-T cell therapy for relapsed/refractory lymphoma.

Fosun Kite's CAR-T product axicabtagene was approved, priced around RMB 1.2 million, opening the first year of commercial cell therapy in China.

The Shanghai Proton and Heavy Ion Hospital is China's first and the world's third institution with both proton and heavy-ion radiotherapy equipment.

The hospital published China's first survival report for proton/heavy-ion radiotherapy, with annual treatment volume exceeding 1,000 cases for three consecutive years.

Fujian Union Hospital completed Fujian's first heavy-ion therapy for liver cancer.

The team of Academician Dong Jiahong completed the first da Vinci robotic precise liver cancer resection.

Zhongshan Hospital performed the world's first simultaneous da Vinci robotic radical rectal cancer resection with liver and lung metastasis resection.

A domestic heavy-ion therapy device was installed, marking localization of heavy-ion radiotherapy equipment.

A domestic PD-1 monoclonal antibody was approved, bringing China's tumor immunotherapy into the localization era.

China established a transarterial chemoembolization (TACE)-centered interventional system, a main treatment for intermediate-advanced liver cancer.

Domestic CAR-T cell therapy completed its first clinical application in North China, advancing regional accessibility.

Multiple top Chinese hospitals use the da Vinci robot for precise minimally invasive resection of lung and esophageal cancers.

The hospital's clinical standard operating procedures (SOP) were updated to 66 items, with treatable disease types expanded to nearly 50.

The hospital combined respiratory gating with pencil-beam scanning for liver and lung radiotherapy, overcoming respiratory-motion localization.

Academician Wang Zhongcheng of Beijing Tiantan Hospital completed China's first DBS surgery in 1998, pioneering surgical treatment of Parkinson's disease.

Professor Zhang Jianguo completed the first domestic brain pacemaker implant in 2009, breaking the import monopoly.

Tsinghua University and Tiantan Hospital co-developed the world's first high-field MRI-compatible brain pacemaker, approved in 2022.

The team of Zhang Jianguo completed the first four-channel directional-electrode DBS clinical trial implant.

Huashan Hospital, Fudan University co-completed China's first invasive brain-computer interface clinical trial.

Professor Jiang Weijian completed China's first intracranial (vertebrobasilar) intravascular stent angioplasty in 2001.

Professor Liu Jianmin completed China's first intracranial aneurysm stent-assisted embolization in 2000.

Beijing Tiantan Hospital completed China's first vagus nerve stimulation for refractory epilepsy in 2004, entering the neuromodulation era.

The team of Gao Feng applied robot-assisted mechanical thrombectomy for the first time globally, published in JAMA Neurology.

The domestic Jiaolong thrombectomy stent was applied for acute middle cerebral artery occlusion, achieving localization of intracranial thrombectomy devices.

The team of Liu Jianmin created a flow-diverter treatment system for cerebral aneurysms, winning Shanghai's first prize for technological invention.

The team of Duan Feng completed China's first interventional brain-computer interface-assisted motor recovery trial.

The team of Wang Zhongcheng successfully resected a 9 cm giant intracranial aneurysm, setting a neurosurgical record.

The team of Wang Zhongcheng pioneered microsurgical treatment of brainstem tumors, conquering a neurosurgical "forbidden zone".

Shanghai Sixth People's Hospital completed the world's first limb replantation in 1963, opening a new field of microsurgery.

Academician Tian Wei's team completed the world's first ultrasonic-bone-scalpel robot-assisted thoracic ossified ligamentum flavum resection.

Tian Wei's team completed the world's first robot-assisted minimally invasive spinal internal fixation based on 3D virtual imaging.

Jishuitan Hospital completed the world's first robot-assisted atlantoaxial transarticular screw fixation, conquering upper-cervical deformity.

Jishuitan Hospital applied a 3D-printed integrated prosthesis for old tibial plateau fracture, a first in China.

Jishuitan Hospital hand surgery developed China's first-generation total wrist prosthesis and completed the first 3D-printed total wrist replacement.

Jishuitan Hospital hand surgery completed the world's first 3D metal-printed midcarpal joint replacement.

Jishuitan Hospital foot-and-ankle surgery completed China's first domestic custom 3D-printed total ankle replacement.

Jishuitan Hospital completed a 3D-printed custom partial hip replacement, offering a hip-preserving option for femoral head necrosis.

Chen Chao's team pioneered four-finger total reconstruction, winning first place in the 2025 world's most challenging microsurgical reconstruction competition.

Tongji-affiliated Tongji Hospital's replantation center completed toe-to-finger reconstruction under high-magnification microscopy.

Tian Wei's team developed the "TiRobot" orthopedic robot, the only internationally capable full-segment spinal surgery robot system.

Zhou Yixin's team completed the first domestic-robot-assisted total hip replacement with globally first individualized prosthesis positioning.

Zhou Zongke's team at West China Hospital completed the first joint replacement assisted by the fully domestic HX robotic arm.

The West China Union University School of Dentistry, founded in 1917, was China's first higher dental school and the origin of modern Chinese stomatology.

Sichuan University's stomatology ranks QS #12 globally and ShanghaiRanking #4, No.1 in China.

The Ninth People's Hospital completed digital titanium-pin-free navigated dental implantation.

Academician Zhao Yimin's team completed the world's first autonomous oral surgical robot jaw reconstruction, covered by CCTV News.

China developed the world's first autonomous oral surgical robot, enabling precise autonomous execution of implantation.

Tian Lei's team completed the world's first robot-assisted one-day "bone-tooth combined" jaw reconstruction.

West China Stomatology Hospital established a multidisciplinary sequential treatment system for cleft lip and palate.

The Ninth Hospital completed China's first implant-supported fixed ear prosthesis, offering reconstruction for ear-loss patients.

The Ninth Hospital completed simultaneous vascularized bone grafting and implantation after mandibulectomy for functional jaw reconstruction.

West China developed the world-first intelligent minimally invasive maxillofacial surgical robot, winning a gold award in China's international student innovation contest.

West China developed the world's first distributed visible-light positioning system for "AR+AI" implantation navigation, with Class III device registration.

The Ninth Hospital advances clinical application of maxillofacial AI and big data in cleft lip/palate diagnosis and treatment.

The Ninth Hospital's oral and maxillofacial surgery has long been in China's first tier — a highland for treatment and training.

West China Stomatology Hospital advances digital surgical techniques in maxillofacial defect repair and implantation.

Zhou Xingtao's team completed the world's first protein-delivery-vehicle (PDV) gene-editing treatment for corneal dystrophy.

The Eye and ENT Hospital of Fudan University completed China's first SMILE Pro femtosecond laser myopia surgery.

Zhongshan Ophthalmic Center completed the world's first 5G robotic remote subretinal injection across 4,200 km.

Academician Xie Lixin's team completed the world's first bioengineered corneal transplant, a historic leap in regenerative medicine.

Shi Weiyun's team developed a fully independent-IP button-type artificial cornea, approved in 2021.

The domestic cochlear implant completed its first human implantation, breaking the import monopoly.

The domestic 3.0T MRI-compatible cochlear implant completed its first implantation.

The domestic cochlear implant completed its first implantation after inclusion in centralized volume-based procurement, sharply lowering patient burden.

China completed ICL implantation at 3,800 m altitude, validating accessibility of ophthalmic surgery at high altitude.

Wu Hao's team completed a high-difficulty auditory brainstem implant, precisely placing a 5 mm electrode array into the auditory center.

Shi Weiyun's team conquered key techniques for porcine-to-human corneal transplantation, easing donor shortage.

He Eye Hospital and Johnson & Johnson built a refractive cataract solution using seventh-generation femtosecond laser for precise functional IOL implantation.

Shi Weiyun's team developed a new corneal storage solution extending viability from 48 hours to 2 weeks, internationally advanced.

Wu Hao's team built an otoneurosurgical skull-base system centered on nerve-function preservation, with over 5,000 operations.

Li Zhaoshen's team at Changhai Hospital was among the earliest to perform ERCP stone extraction, with nearly 2,000 cases per year.

Li Zhaoshen's team completed the world's first natural-orifice transluminal endoscopic surgery (NOTES) liver cyst fenestration.

Changhai Hospital first used EUS-guided iodine-125 seed implantation for advanced pancreatic cancer, published in Endoscopy.

Professor Jin Zhendong completed the first endoscopic pancreatic pseudocyst surgery in 2001, opening the endoscopic era for pancreatic cystic disease.

In the 1980s, Changhai Hospital and others pioneered endoscopic ultrasound in China, training a large number of EUS physicians.

Changhai Hospital treats 90%–95% of pancreatic pseudocysts endoscopically, establishing a mature interventional system.

Changhai Hospital completed a 514-case EUS-FNB study, advancing liquid-based cytology in pancreatic diagnosis.

Changhai Hospital completed a meta-analysis of EUS-guided biliary drainage (42 studies, 1,192 cases), confirming efficacy and safety.

Linghu Enqiang's team performed EUS-guided lauromacrogol ablation of pancreatic cystic tumors, safe and effective.

Changhai Hospital performed EUS-guided celiac plexus iodine-125 implantation, markedly relieving intractable pancreatic cancer pain.

Zhang Zhengang and Cheng Bin's team completed EUS-guided partial splenic artery coil embolization for portal hypertension.

Zou Xiaoping's team performed EUS-guided portal pressure gradient measurement as an alternative to hepatic venous pressure measurement.

Renji Hospital completed endoscopic resection of an ileocecal laterally spreading tumor (LST), demonstrating high-difficulty endoscopy.

Xijing Hospital conducted EUS-guided gastrojejunostomy research, advancing endoscopic anastomosis.

Professor Zhang Lizhu's team at Peking University Third Hospital delivered mainland China's first test-tube baby on 10 March 1988.

Peking University Third Hospital delivered mainland China's first gamete intrafallopian transfer (GIFT) baby in 1988.

Peking University Third Hospital delivered mainland China's first donor-egg IVF baby, expanding assisted-reproduction indications.

Peking University Third Hospital delivered mainland China's first frozen-embryo IVF baby, advancing embryo cryopreservation.

China completed the world's first MALBAC single-gene-disease screening IVF baby, a breakthrough in preimplantation genetic diagnosis.

Fudan's Obstetrics & Gynecology Hospital (Red House) completed the world's first mid-pregnancy uterus-preserving radical cervicectomy.

The Red House Hospital delivered East China's first IVF baby in 1995.

China completed the world's first PGT-P (polygenic-disease preimplantation genetic testing) IVF baby.

Fudan Children's Hospital performed congenital heart surgery on a 1,070 g extremely-low-birth-weight newborn.

Shanghai completed its first Norwood procedure for neonatal hypoplastic left heart syndrome.

Multiple Chinese pediatric centers have completed conjoined-twin separation, demonstrating comprehensive pediatric surgery capability.

China performs fetal intrauterine surgery for prenatal intervention of birth defects.

Zheng Mengzhu, mainland China's first IVF baby, gave birth, validating the long-term safety of assisted reproduction.

Hysteroscopic minimally invasive surgery is widely used in China for precise diagnosis and treatment of endometrial lesions.

Chen Jingyu's team completed the world's first bilateral lung transplant for a COVID-19 case in Wuxi in 2020.

Chen Jingyu's team completed Asia's first off-pump sequential bilateral lung transplant.

Chen Jingyu's team completed China's first simultaneous liver-lung transplant, conquering end-stage multi-organ disease.

Professor Xin Yuling first attempted clinical lung transplantation in 1979, pioneering the field in China.

China completed gene-edited porcine lung transplant research, a milestone for xenotransplantation, published in Nature Medicine-related studies.

China completed the world's first lung and trachea combined transplant, conquering the trachea-transplant challenge.

Zhong Nanshan's team completed the international first 5G remote bronchoscopic robotic biopsy.

China pioneered endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) for lung cancer mediastinal staging.

China-Japan Friendship Hospital performed lung transplant with simultaneous coronary bypass on two patients — a model of multidisciplinary collaboration.

Chen Yuping and Zhang Zhitai completed China's first successful single lung transplant in 1995.

Beijing Anzhen Hospital completed a bilateral sequential lung transplant in 1998, improving success rates.

Chen Jingyu's team has completed nearly 1,000 lung transplants, over half the national volume, with multiple Asian firsts.

Chen Jingyu's team used ECMO (extracorporeal membrane oxygenation) to rescue critical COVID-19 patients, bridging to lung transplant.

China performs airway stent placement for minimally invasive treatment of airway stenosis and tumors.

United Imaging launched the world's first 2-meter total-body PET-CT (uEXPLORER), with 40× sensitivity and scans under 30 seconds.

Lu Qingsheng's team completed the world's first robotic endovascular repair of thoracic aortic aneurysm, entering the robotic endovascular era.

Changhai Hospital completed the world's first robotic endovascular repair of abdominal aortic aneurysm, cutting fluoroscopy time by 90%.

Lu Qingsheng's team developed the world's first universal interventional surgical robot for remote, standardized, precise procedures.

Lu Qingsheng's team completed the world's first automated robot-assisted EVAR, published in MedComm.

Changhai Hospital completed the world's first robotic lower-limb artery stent angioplasty.

Zhang Bili's team completed China's first domestic-robot-assisted fully remote coronary intervention.

Changhai Hospital built the world's first 5G+VR smart cath lab with 360° real-time VR presentation.

Chen Mao's team completed the international first transcatheter mitral valve implantation (TMVI) for rheumatic mitral disease.

West China Hospital completed transcaval transcatheter aortic valve replacement, a new option for patients with difficult vascular access.

Aopeng Medical and Changhai Hospital achieved fully automated EVAR (guidewire and stent release without manual intervention) in 4 patients with 100% success.

United Imaging and Neusoft have localized high-end CT, MRI, and other imaging equipment, breaking the import monopoly.

Changhai Hospital completed China's first endovascular repair of abdominal aortic aneurysm in the 1990s, pioneering the field.

Preoperative 3D-printed vascular models validate millimeter-level precision and standardized operation.

Academician Wu Jieping completed China's first cadaveric kidney transplant in 1960, pioneering organ transplantation in China.

Professor Mei Hua completed China's first living-related kidney transplant in 1972, with the recipient surviving over a year.

Zhang Shize of Ruijin Hospital completed China's first and Asia's first orthotopic heart transplant in 1978.

In 1977, Ruijin Hospital and Wuhan Tongji performed clinical liver transplantation, making China the first Asian country to do so.

Professor Xin Yuling first attempted clinical lung transplantation in 1979.

Professor Fan Sheung-tat of Hong Kong completed the international first living-donor right-lobe liver transplant in 1996.

Renji Hospital leads globally in pediatric liver transplant volume among single centers, a key base for pediatric transplantation.

West China Hospital is the origin of organ transplantation in western China, completing the world's first intrahepatic bile-duct stone liver transplant in 2000.

Xia Suisheng and Chen Shi completed the Asia-Pacific's first pancreatic transplant in 1982.

Chen Shi completed the first one-stage combined pancreas-duodenum-kidney transplant in 1989.

Professor Liu Xiaocheng completed China's first combined heart-lung transplant in 1993.

Academician Li Jieshou completed China's first small-bowel transplant in 1994.

Professor Huang Jiefu completed China's first combined liver-kidney transplant in 1996.

Xijing Hospital completed the world's first transgenic porcine liver xenotransplant in 2024, pioneering the field.

Zhongshan endoscopy center resected an esophageal leiomyoma via submucosal tunneling endoscopic resection (STER), avoiding thoracotomy.

Zhongshan endoscopy center radically resected a hypopharyngeal hemangioma via endoscopic submucosal dissection.

Zhongshan endoscopy center removed a retained duodenal foreign body with dual forceps, avoiding laparotomy.

Zhongshan endoscopy center established the international-standard POEM technique for achalasia.

Huashan neurosurgery resected an acoustic neuroma through a 3 cm keyhole with intraoperative facial-nerve electrophysiology.

Huashan neurosurgery performed VITOM 3D exoscope-assisted facial-nerve microvascular decompression.

Huashan neurosurgery resected a tentorial meningioma via 3D exoscope + endoscope through a subtemporal keyhole approach.

Ruijin GI surgery self-developed a 4K ultra-high-definition 3D fluorescence endoscope, localizing core imaging technology.

Ruijin GI surgery completed laparoscopic colon tumor resection in a patient with severe spinal deformity.

Ruijin GI surgery performed laparoscopic two-step pull-through delayed anastomosis, preserving the anus without a stoma.

Ruijin resected two primary tumors (gastric and rectal cancer) simultaneously via laparoscopy through only five ports.

West China biliary surgery performed laparoscopic multi-organ extended radical cholecystectomy reaching open-surgery anatomical standards.

West China Hospital performed Egypt's first ICG fluorescence-guided laparoscopic liver resection, open for international observation.

West China Hospital performed 7 intercontinental remote robotic surgeries across urology, general surgery, and cardiac surgery.